In times of social distancing and stay-at-home order, Dwight the lab mascot has found the perfect occupation: reading about Hedgehog signaling and taste bud cell renewal!
The Barlow lab attended the Cell Biology, Stem Cells and Development graduate program retreat in Breckenridge, CO. Lauren had a poster on taste organoids, and Dany gave a talk on head and neck irradiation and taste.
Erin's abstract was picked for one of only 8 postdoc talks in the Hilde Mangold Postdoctoral Symposium at the Society for Developmental Biology 78th Annual Meeting in Boston in July.
Finally got that Notice of Award for our new R21 to use lingual organoids to determine how cancer drugs that cause taste dysfunction in patients actually impact how taste bud cells renew.
Linda co-organized the 2019 Southwest Society for Developmental Biology Regional Meeting at the University of Colorado Anschutz Medical Campus (March 7-9)
Dany co-authored an editorial "New evidence for fat as a primary taste quality" with Sue Kinnamon (Dept of Otolaryngology, University of Colorado Anschutz Medical Campus)
Linda, Erin, Dany and Ben attended the 1st Identifying Treatments for Taste and Smell Disorders Conference (ITTSD) in Philadelphia, PA (Nov 14-15, 2018)
David's paper was published in Development "SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis."
Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA.Development. 2018 Jul 17;145(14). pii: dev1648
Using a combination of conditional genetics and a Hedgehog pathway inhibitor, David showed that SOX2 is required downstream of Hedgehog signaling for differentiation of taste bud cells, as well as reveal a more general requirement for SOX2 in tongue epithelium renewal.
Dany's article "β-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice" was published in PLOS Genetics
Dany and Linda's article "β-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates" was published in PLOS Genetics!